Patents by Inventor Albert B. Crum 

COMPOSITIONS AND METHODS FOR THE TREATMENT OF COVID-19

Publication number: 20230233498

Abstract: Embodiments of the present invention relate generally to compositions and methods and uses thereof for preventing, treating or ameliorating the symptoms of Coronavirus (CoV) infections, for example, the novel coronavirus disease 2019 (COVID-19) that is caused by SARS-CoV-2, in a subject in need thereof. Such compositions comprise certain metallothionein analogs, e.g., compositions comprising a glutathione precursor and a selenium source that elevate intracellular glutathione. The methods comprise administering to the subject a composition, e.g., a composition comprising a glutathione precursor and a selenium source, which is capable of inhibiting the intracellular replication and/or infectivity of coronaviruses, particularly the SARS-CoV-2 virus or viral particles thereof. https://patents.justia.com/patent/20230233498

Type: Application

Filed: June 25, 2021

Publication date: July 27, 2023

Inventors: Albert B. CRUM, Laura LILE

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Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

Patients with moderate and severe COVID-19 illness had lower levels of glutathione and higher ROS and ROS/GSH ratio in plasma than patients with mild disease, clearly indicating glutathione deficiency and oxidative stress signs in patients with serious disease manifestations. Full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263077/ 

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The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 Full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402141/

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Could glutathione depletion be the Trojan horse of COVID-19 mortality? 

This preclinical study shows that GSH depletion may have a central role in COVID-19 mortality and pathophysiology. Therefore, elevating the GSH level in tissues may decrease the severity and mortality rates of COVID-19. 

Full article: https://pubmed.ncbi.nlm.nih.gov/33336769/ 

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Glutathione Supplementation as an Adjunctive Therapy in COVID-19

Full article: https://pubmed.ncbi.nlm.nih.gov/32992775/

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Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Full article: https://pubmed.ncbi.nlm.nih.gov/32322478/